Contains the complete text of evaluative monographs from AHFS Drug Information and the Handbook on Injectable Drugs. DIFT contains detailed information on virtually every single-drug entity available in the United States, including some investigational drugs and intravenous infusion solutions as well as commercial drugs. Data on concentration, usage, stability, pH, dosage, administration, compatability, chemistry, pharmacology, interactions and toxicity are included.
The following alphabetical list provides the two-letter label, the relevant alias, and an example for each Drug Information Fulltext database field.
===== ============ Label Name/Example ===== ============ ab Primary Text [Word Indexed] example 1: 557$.ab. example 2: intravenous injections.ab. an Accession Number [Phrase Indexed] example: 582162.an. at Additional Text [Word Indexed] example: guanidine.at. cr References [Word Indexed] example 1: hardy ae.cr. example 2: hardy.cr. de Descriptors [Word and Phrase Indexed] example 1: 5152.de. example 2: 515$.de. example 3: 51$.de. example 4: dosage schedule.de. di Drug Information [Word Indexed] example: dph.di. gn Generic Drug Name [Word Indexed] example: phenytoin sodium.gn. rn CAS Registry Number [Word Indexed] example: 630 93 3.rn. sh Section Heading [Word Indexed] example: drug interactions.sh. so Source [Word Indexed] example: injectable drugs.so. sy Synonyms [Word Indexed] example: diphenylhydantoin.sy. ta Table Data [Word Indexed] example: antibody testing.ta. tc Therapeutic Classification [Word Indexed] example 1: 28 12 12.tc. example 2: 28 12.tc. example 3: 28.tc. example 4: hydantoins.tc. th Table Headings [Word Indexed] example: vaccine.th. ti Title [Word Indexed] example: phenytoin sodium.ti. tn Trade Name Manufacturer [Word Indexed] example 1: dilantin.tn. example 2: parke davis.tn. tx Text (from AB and AT fields) example 1: microcrystal formation.tx. up Update Code [Phrase Indexed] example: 9607.up.
The following limits are available from the Limit menu on the Main Search Screen:
Source Publication... American Hospital Formulary Service Handbook on Injectable Drugs
Command Syntax: ..c/dift Sentence Syntax: use dift
Accession Number
582162.
Update Code
9607
Source
HANDBOOK ON INJECTABLE DRUGS.
Title
Phenytoin Sodium.
Generic Drug Name
PHENYTOIN SODIUM.
Trade Name Manufacturer
Dilantin (Parke-Davis).
CAS Registry Number
630-93-3.
Therapeutic Classification
Hydantoins (28-12-12).
Descriptors
(5152) pH (Table)
(5155) pH
(5172) Osmolarity osmolality (Table)
(5175) Osmolarity osmolality
(5405) Preparations
(5412) Other ingredient ion (Table)
(5415) Other ingredient ion
(5515) Special instruction
-sample list truncated-
Section Heading
PRODUCTS.
PH.
OSMOLALITY.
SODIUM CONTENT.
DOSAGE.
STABILITY.
SORPTION.
FILTRATION.
ADDITIONAL COMPATIBILITY INFORMATION.
SOLUTIONS.
GENTAMICIN.
CONCENTRATED SOLUTIONS.
SECTION HEADINGS/SUBHEADINGS (ADDITIONAL TEXT):
PRODUCTS.
PH.
OSMOLALITY.
COMPATIBILITY INFORMATION.
ADDITIONAL COMPATIBILITY INFORMATION.
SOLUTIONS.
Primary Text
(1 of 18)
SECTION HEADING: PRODUCTS.
(5405) Phenytoin sodium (Parke-Davis) is available as a ready-mixed
solution in 100-mg (2 ml) vials and disposable syringes and 250-mg
(5 ml) vials.
(2 of 18)
SECTION HEADING: PRODUCTS.
SUBHEADING: PH.
(5155) The USP range is 10 to 12.3 (17). The pH of the Parke-Davis
product is adjusted to 12 (2).
(3 of 18)
SECTION HEADING: PRODUCTS.
SUBHEADING: OSMOLALITY.
(5175) The osmolality of phenytoin sodium (Parke-Davis) 50 mg/ml was
determined to be 9740 mOsm/kg by freezing-point depression and 6175
mOsm/kg by vapor pressure (1071). Another report indicated that the
osmolality of phenytoin sodium 50 mg/ml was 3035 mOsm/kg by
freezing-point depression (1233).
- sample text truncated -
Table Data
[5412] Each milliliter of solution contains (2):
[5152] The apparent pH of multiple lots of phenytoin sodium from
several manufacturers was evaluated. The lower apparent pH of some
products ma play a role in microcrystal formation on dilution (1514):
[5172] The osmolality of phenytoin sodium 500 mg was calculated for
the following dilutions (1054):
(1 of 8)
[5412] Each milliliter of solution contains (2):
Phenytoin sodium 50 mg
Propylene glycol 40%
Alcohol 10%
Sodium hydroxide to adjust pH
Water for injection qs
- sample text truncated -
References
For a list of references cited in the text of this monograph, search
the monograph titled HID References.
Additional Text
(1 of 8)
SECTION HEADING: PRODUCTS.
SEE TABLE FORMAT OF THIS RECORD.
(2 of 8)
SECTION HEADING: PRODUCTS.
SUBHEADING: PH.
SEE TABLE FORMAT OF THIS RECORD.
(3 of 8)
SECTION HEADING: PRODUCTS.
SUBHEADING: OSMOLALITY.
SEE TABLE FORMAT OF THIS RECORD.
- sample text truncated -
This database is copyrighted by the American Society of Health System Pharmacists, Inc. No part of this database may be duplicated in hard-copy or machine-readable form without written authorization from the American Society of Health System Pharmacists. The American Society of Health System Pharmacists represents that the database provided hereunder was formulated with a reasonable standard of care, and in conformance to professional standards in the field. Except with respect to the foregoing and as otherwise specifically provided in this agreement, the American Society of Health System Phatmacists makes no representations or warranties, expressed or implied, including but not limited to, any implied warrant of merchantability or fitness for a particular purpose, with respect to such database and specifically disclaims all such warranties and representations. Users are advised that decisions regarding drug therapy are the responsibility of the clinician; and that this database (DIFT) is provided for information purposes only. The entire monograph for a drug should be reviewed for a through understanding of the drug's actions, uses, and side effects.
Revised 21 March, 1997