The EMBASE Drugs and Pharmacology (EMDP) database is a member of the EMBASE family that consists of three separate databases: the Excerpta Medica Database (EMBASE), EMBASE Drugs and Pharmacology (EMDP), and EMBASE Psychiatry (EMPS). Formally, EMDP and EMPS are considered to be subsets of EMBASE. This field guide, although very similar in content to those of EMBASE and EMPS, provides a scope of information specific to the EMBASE Drugs and Pharmacology (EMDP) database.
The EMBASE Drugs and Pharmacology (EMDP) database, produced by Elsevier Science, contains the most important citations and abstracts to the worldwide drug literature. It is a subset of EMBASE, the Excerpta Medica database, which indexes more than 3,500 international journals in the following fields: drug research, pharmacology, pharmaceutics, toxicology, clinical and experimental human medicine, health policy and management, public health, occupational health, environmental health, drug dependence and abuse, psychiatry, forensic medicine, and biomedical engineering and instrumentation. The database allows searchers to focus on the pharmaceutical industry. Coverage includes effects, use, and administration of all current, potential and experimental drugs, side effects, manufacturers, and trade names of approved and prospective drugs.
The following alphabetical list provides the two-letter label, the relevant alias, and an example for each EMDP field.
===== ============
Label Name/Example
===== ============
AB Abstract [Word Indexed]
mitral valve prolapse.ab.
EMDP includes author-written abstracts when they are available.
Approximately 60% of the citations in EMDP include abstracts.
AF All Searchable Fields
drug abuse.af.
All Fields (AF) is an alias for all of the fields which occur in the
source documents, including value-added fields such as Subject Headings.
The only thing excluded from an All Fields search are fields such as
"floating subheading" or "Heading word" which are created by the loading
process and do not actually appear in the record.
AN, UI Accession Number [Phrase Indexed]
2000243944.an.
The Accession Number (AN) field contains a ten-digit number assigned
in EMDP to uniquely identify a particular record.
AU Author [Phrase Indexed]
smith $.au.
The Author (AU) field contains up to 100 authors in the format of
last name and one or more initials. If a single initial could not
be transliterated with one letter, two or more letters may be used.
Occasionally a name will include the full first name.
If there are more than 100 authors, only 99 are listed, followed by
the indication "et al."
CD Journal CODEN [Phrase Indexed]
aajnd.cd.
The Coden (CD) field contains a journal CODEN. CODENS are 5-digit codes
such as "AJDCA" which uniquely identify a journal title.
CF Conference Information [Word Indexed]
tokyo.cf.
The Conference Information (CF) field contains supplementary information
about a conference such as its location. Conference information usually
is displayed as part of the source.
Individual words are indexed in the CF field; enter a single descriptive
word such as "japan".
CP Country of Publication [Phrase Indexed]
france.cp.
The Country of Publication (CP) field contains the full name of the
country in which a journal was published. The Country of Publication
appears as part of the Source (SO), but can also be displayed
separately. The country name is entered into the index as a phrase.
DV Device Trade Name [Word Indexed]
ultrasound.dv.
DM Device Manufacturer [Phrase Indexed]
life technologies.dm.
The Device Trade Name (DV) field contains the medical device trade names
assigned to the records. The Device Manufacturer (DM) field contains the
device manufacturer name associated with the Device Trade Name. These
fields display together in the citation.
DP Date of Publication [display only]
The Date of Publication (DP) field contains the month, year, and
possibly day that the journal was published. In addition, it displays
as part of the Source field.
Note: Only weekly journals, such as The Lancet display a
Date of Publication.
EC Embase Section Headings [Phrase Indexed]
032.ec.
The EMBASE Section Headings (EC) field contains the section assignment
numbers that correspond to the Excerpta Medica Abstract Journals and
Literature Indexes.
There are fifty-two codes indexed as three digits (001 through 052). To
search this field, enter the desired code.
EM, UP, IM, ND, IR, EW Entry Week [Phrase Indexed]
199901.em.
The Entry Week (EM) field contains the date (year and week) in which
a document was added to EMDP.
FS Floating Subheading [Phrase Indexed]
an.fs.
Subheadings, or "link terms" are qualifiers added to EMTREE subject
headings to refine their meaning. Terms such as "adverse drug reaction"
or "drug toxicity", when combined with an EMTREE term, give a very
precise idea of what an article covers.
The Floating Subheadings (FS) field contains the 2-letter link terms,
such as "AN" for drug analysis.
HW, ME Heading Word [Word Indexed]
antigen.hw.
Sometimes you may wish to retrieve every EMTREE subject heading that
includes a particular word; this is done by searching the single word in
the Subject Heading Word (HW) field.
IB ISBN [Phrase Indexed]
0444813543.ib.
The ISBN (IB) field contains the International Standard Book Number (ISBN)
for a book or monographic publication.
IN Institution [Word Indexed]
tufts.in.
The Institution (IN) field contains the primary author's affiliation,
which is usually the source for a reprint of the article.
This information is not standardized and often contains abbreviations.
Enter the single most descriptive word in an institution (harvard, not
university). Consider both full spellings and abbreviations.
Beginning in 1997, the primary author's e-mail address will be included
when provided in the original source material.
IS ISSN [Phrase Indexed]
0028-4793.is.
The ISSN (IS) field contains the International Standard Serial Number
(ISSN) for the journal in which an article was published.
JN, JT Journal Name [Phrase Indexed]
biological psychiatry.jn.
archiv$.jn.
The Journal Name (JN) field contains the full name of the journal in which
an article was published.
Journal names are indexed as phrases; so be sure to enter enough letters of the
journal name to locate the name in the index, as in new engl.jn. for New
England Journal of Medicine.
Stopwords such as "of" ARE included in the JN index, but when "the" is
the first word of a journal, it has been stripped.
JW Journal Word [Word Indexed]
internal medicine.jw.
The Journal Word (JW) field contains individual words from every
journal name in EMDP.
Stopwords such as "the" or "of" are not included. This field is used to
retrieve every occurrence of a journal which includes a particular word,
such as "pharmacology."
LG, LA Language [Phrase Indexed]
fre.lg.
The Language (LG) field contains the language(s) of publication of an
article. The language name will appear in the index as a 3-letter code
(such as fre for french) or as the full language name. The codes are
usually, but not always, the first three letters of the language name.
For a spelled-out list of languages, refer to the Limit/Languages
Pulldown menu.
MF Drug Manufacturer Name [Phrase Indexed]
lilly.mf.
The Drug Manufacturer Name (MF) field contains the full name of the
manufacturer of a drug or device discussed in an article. Manufacturer
names are listed in their brief form, for example, "Lilly" for "Eli
Lilly." Enter the first few letters of a manufacturer name and you
will be shown the index of names beginning with those letters.
MS Molecular Source Number [Word Indexed]
K0083.ms.
The Molecular Sequence Number (MS) field contains an acronym for
a source of molecular sequence data and a sequence accession number
documented by the source. Each acronym is preceded by a weighting
of A or B in parentheses. The weighting of A is assigned to the
sequence numbers whose submission to a molecular sequence database
is announced in the document indexed. The weighting of B is
assigned to sequence numbers, which are referred to, but not
submitted by the document.
To search this field, enter the sequence accession number. The
search can be combined with the source and the weighting. For
example, one could enter K0083.ms. and A.ms. to retrieve items
where K00083 is announced in the indexed document.
The field displays in the citations as follows:
(B)Genebank: K00083; (A)EMBL: X1614; (B)SWISSPROT: P25808.
OT, TT Original Title [Word Indexed]
heure.ot.
The Original Title (OT) field contains all non-English titles in the
original language. If the original title was in a non-Roman alphabet,
then the OT is transliterated.
Omit common articles when searching a foreign language: heure
not l'heure.
PB Publisher [Word Indexed]
elsevier.pb.
The Publisher (PB) field includes the publisher name for a book or other
non-journal publication. Enter the most distinctive part of a name to
locate a publisher, as in elsevier.pb.
This field is usually displayed as part of the Source (SO) field.
PT Publication Type [Phrase Indexed]
conference paper.pt.
review.pt.
The Publication Type (PT) field contains one of the following indexed forms of
literature: Article, Book, Conference Paper, Conference Proceeding, Editorial, Erratum,
Journal, Letter, Note, Review, Report, or Short Survey. In addition, information is
presented about the item type as the original document. The item type information is
utilized from 1991 forward. Also, citations now indicate if the original document
was an article conference paper, editorial, erratum, letter, note, review, or short survey.
To search the PT field, enter the appropriate literature type search term, such as
short survey.pt.
RN Registry Number [Phrase Indexed]
3843-74-1.rn.
The Registry Number (RN) field contains the Chemical Abstracts Service
Registry number for a compound mentioned in an article.
Registry numbers appear and are searched with hyphens (50-07-0).
SD Source Description [Word Indexed]
"7".sd.
"22".sd.
The Source Description (SD) field contains the volume/issue/part and
pagination of a journal. The SD field usually display as part of the
Source (SO) field.
The SD field is used to supplement the journal name or title when a
particular citation is sought. Enter a single volume/issue or page
number and combine it with searches on other elements of the citation.
SH, DE, CT, SW Subject Headings [Phrase Indexed]
cd4 antigen.sh.
*cd4 antigen/
The Subject Heading (SH) field contains the EMTREE Thesaurus terms used
by EMBASE indexers to describe the content of an article.
EMTREE terms are organized in a hierarchy, or "tree" structure.
EMTREE terms are entered into the index as phrases and should be
searched as they appear in the published EMTREE or in our Tree display.
All EMTREE terms and associated terms are indexed in the SH field.
SL Summary Language [Phrase Indexed]
fre.sl.
The Summary Language (SL) field contains the language(s) of the
summaries (up to three languages) printed in the original document.
The summary language name appears in the index as a 3-letter
code (such as fre ) or as the full language name (french). Often,
the codes are the first three letters of the summary language name.
SO Source (JN, PB, SD, YR, CF, DP)
psycholog$.so.
The Source (SO) field includes a display of all the basic information
needed to locate a citation, including the Journal Name or Monograph
Publisher, the Vol/Issue, pagination, year of publication, Conference
Name or Report Number, and Date of Publication.
TI Title [Word Indexed]
down's syndrome.ti.
prozac.ti.
The Title (TI) field contains the English language version of a title.
For documents which are not written in English, the original or
transliterated title appears in a separate field, Original Title.
The title sometimes includes notes about the article such as an
indication of language.
TN Drug Trade Name [Phrase Indexed]
valium.tn.
The Drug Trade Name and Manufacturer (TN) field contains both the trade name
and manufacturer for a drug or device discussed in an article.
TW Textword (AB, TI, TN)
mitral valve prolapse.tw.
The Textword (TW) field is an alias for all of the fields in a database
which contain text words and which are appropriate for a subject search.
The Textword field in EMDP includes Title (TI) and Abstract (AB).
YR Year of Publication [Phrase Indexed]
1992.yr.
The Year (YR) field contains the year in which an article or monograph
was published. The year must be searched as a single 4-digit number.
The following limits are available from the Limit menu on the Main Search Screen:
Popular Command and Sentence Syntax Limits:
Abstracts Command Syntax: ..l/ ab=y Sentence Syntax: limit 1 to abstracts English Language Command Syntax: ..l/1 en=y Sentence Syntax: limit 1 to english Experimental Subjects Sentence Syntax: limit 1 to amphibia Sentence Syntax: limit 1 to higher plant Sentence Syntax: limit 1 to microorganism Female Sentence Syntax: limit 1 to female Human Command Syntax: ..l/1 hu=y Sentence Syntax: limit 1 to human Human Age Group Sentence Syntax: limit 1 to infant Languages Command Syntax: ..l/1 lg=fre Sentence Syntax: limit 1 to french Latest Update Command Syntax: ..l/1 up=y Sentence Syntax: limit 1 to update Male Sentence Syntax: limit 1 to male Priority Journals Sentence Syntax: limit 1 to priority Sentence Syntax: limit 1 to priority journals Publication Year Command Syntax: ..l/1 yr=1996 Command Syntax: ..l/1 yr=1992-1993 Sentence Syntax: limit 1 to yr=1996 Publication Types Sentence Syntax: limit 1 to review Sentence Syntax: limit 1 to article Routes of Drug Administration Sentence Syntax: limit 1 to intraarterial
SAMPLE DOCUMENT 1: Accession Number 2000159759 Authors Collie-Duguid ESR. Etienne MC. Milano G. McLeod HL. Institution University of Aberdeen, Dept Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen AB25 2ZD; United Kingdom. Country of Publication United Kingdom Title Known variant DPYD alleles do not explain DPD deficiency in cancer patients. Source Pharmacogenetics. Vol 10(3) (pp 217-223), 2000. Subject Headings *Allele *Cancer Patient *Enzyme Deficiency/co [Complication] *Enzyme Deficiency/et [Etiology] Blood Toxicity/si [Side Effect] Cancer/dt [Drug Therapy] Drug Toxicity/si [Side Effect] Enzyme Activity Exon Gene Mutation Gene Sequence Genetic Polymorphism Genotype Intron Molecular Biology Nucleic Acid Base Substitution Phenotype Human Controlled Study Clinical Article Clinical Trial Male Female Article Nucleotide Sequence Priority Journal *Dihydropyridine/ec [Endogenous Compound] Fluorouracil/ae [Adverse Drug Reaction] Fluorouracil/ct [Clinical Trial] Fluorouracil/dt [Drug Therapy] Abstract Dihydropyrimidine dehydrogenase (DPD) degrades over 80% of administered 5-fluorouracil (5FU), thereby regulating the efficacy of this commonly used anticancer agent. DPD activity is highly variable (8-21-fold) and individuals with reduced activity have a high risk of 5FU toxicity. DPYD encodes DPD protein and 13 different mutations have been reported in DPD-deficient subjects. However, the contribution of these variant genotypes to polymorphic DPD activity in vivo is not clear. The previously described DPYD mutations are contained in 10 exons. These 10 exons were sequenced in a cohort of cancer patients with reduced (n = 23) or normal (n = 14) DPD activity to determine the contribution of each variant allele to low DPD activity in vivo. Eight of the 13 previously defined DPYD mutations (G62A, DeltaTCAT295-298, C703T, G1003T, G1156T, DeltaC1897, G2657A, and G2983T) were not detected. A previously defined exon 13 mutation (G1601A) was detected in three individuals with reduced DPD activity. An exon 14 splice donor site mutation (intron 14 G1A) was detected in a normal DPD activity individual. It was demonstrated that T85C, A1627G and C2194A are common polymorphisms. A novel exonic mutation (T1679G) was detected in a patient with reduced DPD activity and 5FU toxicity. In addition, three novel common polymorphisms were detected in introns 10 and 13. Only three patients did not have any mutations and 30 had multiple DPYD mutations in the regions examined. However, only 17% (4/23) of the patients with a low DPD phenotype have a molecular basis for reduced activity. Although novel DPYD variants have been identified in this study, the 17 DPYD mutations now described do not entirely explain polymorphic DPD activity and toxic response to 5FU. These data emphasize the complex nature of the molecular mechanisms controlling polymorphic DPD activity in vivo. (C) 2000 Lippincott Williams and Wilkins. CAS Registry Numbers 27790-75-6. 51-21-8 ISSN 0960-314X CODEN PHMCE Language English Summary Language English Publication Type Journal: Article Entry Week 200020 Molecular Sequence Number (B)GENBANK: HS009178 EMBASE Section Headings 016, 022, 030, 037, 038 Copyright *COPYRIGHT ELSEVIER SCIENCE B.V. 2001 - ALL RIGHTS RESERVED*SAMPLE DOCUMENT 2: Accession Number 1999299194 Authors Minchin RF. Orr RJ. Cronin AS. Puls RL. Institution Department of Pharmacology, University of Western Australia, Nedlands, WA 6907; Australia. Country of Publication Croatia Title The pharmacology of gene therapy. Source Croatian Medical Journal. Vol 40(3) (pp 381-391), 1999. Subject Headings *Gene Therapy Expression Vector Gene Targeting Genetic Engineering Gene Transfer Gene Expression Transgene Genetic Transfection Review DNA Ganciclovir Abstract The objective for human gene therapy is to express exogenous DNA at a site in vivo for long enough, and at sufficient levels to produce a therapeutic response. The obstacles to this objective are numerous and include the formulation or packaging of the DNA, in vivo delivery, penetration of biological barriers, DNA elimination within the cell and from the tissue compartments of the whole body control of product expression and overt toxicity. The current challenge is to resolve each of these obstacles to produce a practical and efficient gene therapy. In doing so, it is vital to understand the disposition of DNA vectors in vivo, and to know how conventional medicines may be used to modulate this disposition and to enhance the therapeutic effect of these vectors. Many of the general concepts of human gene therapy have been reviewed extensively in the literature. This review discusses some of the pharmacological aspects of gene delivery and the fate of vectors in vivo, and then highlights how drugs are being used to modulate gene therapy. CAS Registry Numbers 9007-49-2. 82410-32-0 ISSN 0353-9504 CODEN CMEJE Language English Summary Language English Publication Type Journal: Review Entry Week 199935 EMBASE Section Headings 022
The databases created by Exerpta Medica are copyrighted by Elsevier Science Publishers B.V. No part of the databases may be copied in machine readable, hard copy or any other form, or made available for the use of any third party without permission of the copyright owner. Elsevier Science Publishers B.V. requires that the user signs a downloading agreement with ESP before the actual downloading takes place. This agreement will be sent to you after contacting one of the Exerpta Medica Marketing offices. Elsevier Science Publishers B.V. represents that EMBASE and EMBASE backfiles, and EMBASE subfiles were formulated with a reasonable standard of care and in conformance to professional standards in the field. Except with respect to the foregoing and as otherwise specifically provided in the agreement, Elsevier Science Publishers B.V., makes no representations or warranties of merchantability or fitness for a particular purpose, with respect to such databases and specifically disclaims all such warranties and representations. Elsevier Science Publishers B.V. also disclaims any legal liability or responsibility for any damages or loss, direct or indirect, sustained by the user of this database.EMBASE Drugs and Pharmacology Copyright Information
Updated 12 March 2001